The show challenged what constituted a typical family structure, resonating with the evolving viewing demographic.
Tony is easygoing and charming.
Angela is straight-laced and focused.

Tony Danza and Judith Light in Who’s the Boss? (1984) | IMDb
Tonys the gut instinct to Angelas objective deduction.
The juxtaposition between the two started with playful banter and teasing.
They had a will-they-wont-they throughline subsisting beneath the surface of each comedic bickering match.

Other (smaller) factors of note:

Tony Danza and Judith Light in Who’s the Boss? (1984) | IMDb

Tony Danza and Katherine Helmond in Who’s the Boss? (1984) | IMDb